In the opinion of the good folks at
Hecklerspray:
16. Prince Lotor - Voltron
15. Miles Mayhem - M.A.S.K.
14. Barpm vpm Greenback - Dangermouse
13. Darkstorm - Visionaries
12. Hugo A-Go-Go - Batfink
11. Starscream - Transformers
10. Venger - Dungeons and Dragons
9. Doctor Claw - Inspector Gadget
8. Zoltar - Battle of the Planets
7. Mumm-ra - Thundercats
6. Gargamel - The Smurfs
5. Shredder - Teenage Mutant Ninja Turtles
4. Cobra Commander - GI Joe
3. Serpentor - GI Joe
2. Megatron - Transformers
1. Skeletor - Masters of the Universe